金艳霞

发布者:生命科学学院发布时间:2020-04-24浏览次数:1522

         金艳霞 (1989.08

博士  硕士生导师    楚天学子   

办公室:生科院8408室  

E-mailjinyanxia@hbnu.edu.cn


个人简历

 ■教育经历

 2019-2020年,武汉大学/香港浸会大学 中医药学院,博士后,香江学者

 2016-2018年,武汉大学 中南医院 血液科,博士后,助理研究员

 2011-2016年,武汉大学 生命科学学院 生物化学与分子生物学专业,获理学博士学位

 2007-2011年,湖北师范学院 生命科学学院 生物科专业,获理学学士学位

 ■工作经历

 2018-至今,湖北师范大学 生命科学学院 任教

 2020.08-2021.07,黄石市服务产业专才支持计划,湖北器长光电股份有限公司,企业技术顾问

研究领域

主要从事肿瘤诊断及治疗方面的科研工作。具体研究领域包括:

 ■非小细胞肺癌早诊标志物筛选;蛋白糖基化修饰鉴定及与肿瘤发生的关系

 ■抗肿瘤药物筛选

主要社会兼职

湖北省临床肿瘤学会(ESCO)免疫治疗专家委员会,委员

湖北省细胞生物学会,会员

承担的课程

本科生:生物化学及分子生物学实验,细胞生物学

主持或参加的课题项目 

早期非小细胞肺癌中α-1-抗胰凝乳蛋白酶的GlcNAc修饰结构鉴定和其功能研究(国家自然科学基金青年项目,No.3200009082021-202324万元,在研,主持)

AACTGlcNAc修饰位点鉴定及其在非小细胞肺癌早期发生中的生物学作用探究(湖北省自然科学青年项目,No.2020CFB4172020-20225万元,在研,主持)

新型GlcNAc修饰的AACT作为NSCLC早期诊断标志物的功能探究(湖北师范大学2018年引进人才科研启动基金,No. HS2019RC0082019-202110万元,在研,主持)

湖北师范大学教学改革研究项目(重点指导类),新形势下生物化学实验课程教学改革的探索与实践,(2020/10-2022/10,在研,主持)

探究植物药物CKI激活免疫抗氧化治疗AML的作用机制(湖北省重点实验室开放基金,No.EWPL2018012019-20202万元,已结题,主持)

运用凝集素亲和-质谱技术筛选多发性骨髓瘤预后监控指标(武汉大学中南医院科研创新培育基金青年项目,2016-20185万元,已结题,主持)

  ■基于ROS信号通路探索壬二酸治疗急性髓系白血病的作用机制(国家自然科学基金面上项目,2018-2021,主要参加者)


代表性成果

期刊论文

  ■Yanxia Jin#, Liqin Cai#, Qian Yang, Ziyi Luo, Li Liang, Yuxing Liang, Balu Wu, Lu Ding, Dongdong Zhang, Xiaojuan Xu, Lina Zhang*, Fuling Zhou*, Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-D-glucan, Carbohydrate Polymers, 2020, 240: 116329. doi: 10.1016/j.carbpol.2020.116329..

  ■Yanxia Jin, Yufeng Shang, Hailing Liu, Lu Ding, Xiqin Tong, Honglei Tu, Guolin Yuan, Fuling Zhou*, A retrospective analysis: a novel index predicts survival and risk-stratification for bone destruction in 419 newly diagnosed multiple myelomas, OncoTargets and Therapy, 2019, 2019:12 10587–10596

  ■金艳霞,王卫东*,刘娜,张新潮,汪劲松,邱昌恩,肺癌早期诊断标志物鉴定研究进展,2019,生命的化学,39(6)1082-1089

  ■Yanxia Jin, Yajun Yang, Yanting Su, Xiangdong Ye, Wei Liu, Qing Yang, Jie Wang, Xiangning Fu, Yongsheng Gong*, Hui Sun*, Identification of a novel diagnostic biomarker of human early non-small cell lung cancer, Glycoconjugate Journal, 2019, 36(1): 57-68

  ■Yanxia Jin, Qian Yang, Li Liang, Lu Ding, Yuxing Liang, Dongdong Zhang, Balu Wu, Tian Yang, Hailing Liu, Tingting Huang, Hui Shen, Honglei Tu, Yunbao Pan, Yongchang Wei, Yi Yang, Fuling Zhou*, Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway, Journal of Experimental & Clinical Cancer Research, 2018, 37: 277

  ■Yanxia Jin, Shishang Guo, Qin Cui, Sichao Chen, Xiaoping Liu, Yongchang Wei, Yunbao Pan, Liang Tang, Tingting Huang, Hui Shen, Guanghui Xu, Xuelan Zuo, Shangqin Liu, Hui Xiao, Fei Chen, Fayun Gong*, Fuling Zhou*, A hospital based retrospective study of factors influencing therapeutic leukapheresis in patients presenting with hyperleukocytic leukemia, Scientific reports, 2018, 8: 294

  ■Chenyang Lu#, Shan Meng#, Yanxia Jin#, Wanggang Zhang, Zongfang Li, Fang Wang, Feng Wang-Johanning, Yongchang Wei, Hailing Liu, Honglei Tu, Dan Su, Aili He, Xingmei Cao, Fuling Zhou*, A novel multi-epitope vaccine from MMSA-1 and DKK1 for multiple myeloma immunotherapy, Br J Haemat, 2017, 178(3): 413-426

  ■Yanxia Jin, Jie Wang, Xiangdong Ye, Yanting Su, Guojun Yu, Qing Yang, Wei Liu, Wenhui Yu, Jie Cai, Xi Chen, Yi Liang, Yijie Chen, Barry Hon Cheung Wong, Xiangning Fu*, Hui Sun*, Identification of GlcNAcylated Alpha-1-antichymotrypsin as an early biomarker in human non-small cell lung cancer by quantitative proteomic analysis with two lectins, Br J Cancer, 2016, 114(5): 532-544

  ■Yanxia Jin, Tao Che, Yalin Yin, Guojun Yu, Qing Yang, Wei Liu, Xiangdong Ye, Wenhui Yu, Shrestha Alok, Yijie Chen, Barry Hon Cheung Wong, Pengfei Cheng, Hui Sun*, Lethal protein in mass consumption edible mushroom Agrocybe aegerita linked to strong hepatic toxicity, Toxicon, 2014, 90C: 273-285

  ■Pan Liu, Yanxia Jin, Haseeb Sattar, Hailing Liu, Weiling Xie, Fuling Zhou*, Natural killer cell immunotherapy against multiple myeloma: progress and possibilities, J Leukocyte Biol, 2018, 103(5):821-828

  ■Li Liang, Yanxia Jin, Xiaoqiang Zhu, Fuling Zhou, Yi Yang*, Real-time detection and monitoring of the drug resistance of single myeloid leukemia cells by diffused total internal reflection. Lab Chip, 2018, 18: 1422-1429

会议论文

  ■Yanxia Jin, Yuxing Liang, Xiqin Tong, Balu Wu, Lu Ding, Fuling Zhou* , Construction of novel patient derived xenograft model in hyperleukocytic acute myeloid leukemia. 2019, the Global Academic Programs. (Poster Accept)

  ■Yanxia Jin, Qian Yang, Li Liang, Lu Ding, Yuxing Liang, Dongdong Zhang, Tian Yang, Mingfeng Zhao and Fuling Zhou*, A potential mechanism for the antioxidant compound kushen injection targeting the ROS signaling pathway in acute myeloid leukemia. 2018, The American Society of Hematology, ASH, Blood, 2018, 132(suppl 1):5221.

  ■Yanxia Jin, Qian Yang, Dongdong Zhang, Lu Ding, Tian Yang, Balu Wu, Fuling Zhou*, The antioxidant compound kushen injection inhibit the acute myeloid leukemia proliferation via the ROS-immune pathway2018年度湖北省医学生物免疫学会第三届年会优秀学术论文

  ■Yanxia Jin, Guolin Yuan, Fuling Zhou*, Innovative discovery of therapeutic plateletpheresis in patients with thrombocytosis using the Fresenius COM.TEC, Proceedings of the American Association for Cancer Research Annual Meeting 2018, AACR, Cancer Research, 2018, 78(suppl 13), pp.1645

  ■Yanxia Jin, Hailing Liu, Lu Ding, Xiqin Tong, Honglei Tu, Pan Liu, Yongchang Wei, Yunbao Pan, Anling Li, Shan Meng, Bo Lei, Guolin Yuan, Xuelan Zuo, Fuling Zhou*, A retrospective study of bone destruction in 419 newly diagosed multiple myeloma: correlation, a novel index predicts survival and risk-stratification2017第十六届全国实验血液学学术会议(Poster Accept

专利

发明专利:一种AACT基因过表达试剂及其制备方法和应用,发明人:金艳霞,孙慧,王卫东,闫梦琴,詹艳,王绮昀,申请号:202011053933.9,公布号:CN112111497A

发明专利:壬二酸在制备抗急性髓系白血病和化疗增敏药物中的应用。周芙玲,潘运宝,金艳霞,丁路,刘盼,专利号:CN106580942B

实用新型专利:一种可拆连的带盖式简易采血管连接卡。周芙玲,金艳霞,曹启龙,左学兰,专利号:ZL201621068000.6

实用新型专利:一种可控速的便携式无菌胸膜腔穿刺仪。魏永长,谢丛华,曹启龙,金艳霞,丁路,专利号:ZL201621156459.1

发明专利:一种高白细胞性白血病PDX模型的建立方法。周芙玲,金艳霞,梁雨星,杨倩,丁路,张冬冬,吴八路,潘运宝,申请号CN201810873359.8,公开号CN109022362A

发明专利:肺癌早期诊断肿瘤标志物的应用及试剂盒。孙慧,叶祥东,金艳霞,王雪晴,申请号CN201910664259.9,公开号CN110501501A

  ■发明专利:靶向MMSA-1嵌合抗原受体修饰T淋巴细胞及其制备方法和应用。周芙玲,童西琴,魏永长,金艳霞,丁路,邵亮,江宏强,灿灿,商御凤,吴八路,申请号CN201911044528.8,公开号CN110885790A


获奖情况

 2018“香江学者计划”入选者,获得“香江学者奖”

 2020年湖北省细胞生物学学会青年教师讲课比赛二等奖

 ■2021年中国细胞生物学学会青年教师讲课比赛二等奖

 指导学生获全国大学生生命科学创新创业大赛指导教师一等奖(创业类)1项和三等奖(创新类2

 指导学生获批大学生创新创业训练计划项目(创新训练)3(国家级1项,No. 202010513001湖北省级2

 指导学生获第六届中国国际“互联网+”大学生创新创业大赛湖北师范大学校级金奖

 指导学生获第六届中国国际“互联网+”大学生创新创业大赛湖北省复赛银奖