刘焕

发布者:生命科学学院发布时间:2024-02-26浏览次数:2237


刘焕  (19917月)

博士 讲师 硕士生导师

E-mail: liuhuanjzcd@126.com

个人经历

教育经历

2018-2022 年,华南农业大学食品科学与工程专业学习,获工学博士学位

2015-2018 年,华南农业大学食品科学专业学习,获工学硕士学位

2011-2015 年,湖北工程学院食品科学与工程专业学习,获工学学士学位

工作经历

2022-今,湖北师范大学生命科学学院任教

研究领域

主要从事食品安全与营养方向的研究工作。具体研究领域包括:

食品中危害因子(塑化剂、甲醛、微塑料等)的污染监测和风险评估。

食品中危害因子肝毒性和神经毒性评价与分子机制研究。

植物活性成分功效评价。

承担的课程

工程制图、食品工程原理、食品工艺学实验。

主持参与的课题项目

食用野生植物保育与利用湖北省重点实验室开放基金重点项目,藜蒿基于5-HT/Wnt/β-catenin通路改善 壬基酚所致神经发育毒性的机制研究,主持。

黄石市科技创新团队,农产品/水产品质量安全监测技术研究与示范科技创新团队,参与。

广东省自然科学基金,基NAD+/SIRT1/MAO-A通路探讨烟酰胺单核苷酸对壬基酚所致学习记忆损伤的干预效应,参与。

广东省联合基金,食用色素及包装材料危害识别与风险评价技术,参与。

国家自然科学基金,基于Nrf2信号通路探讨桑葚多酚类物质对壬基酚神经行为毒性的干预机制,参与。

代表性成果

Environmental microplastic and phthalate esters co-contamination, interrelationships, co-toxicity and mechanisms. A review. Environmental Geochemistry and Health, 2024, 46(12), 525SCI三区,一作

Multi‐Omics Analysis of the Molecular Mechanisms by Which Extract of Artemisia selengensis Turcz. Ameliorates DBP‐Induced Liver Injury. Chemistry & Biodiversity, e202401963SCI三区,通讯作者

Effects of 1, 4-dihydropyridine derivatives on cell injury and mTOR of HepG2 and 3D-QSAR study[J].Computational Biology and Chemistry, 2024, 109, 108010SCI四区,一作

DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway[J]. Food and Chemical Toxicology, 2023, 176: 113782. SCI二区top一作

Effect of DEHP and DnOP on mitochondrial damage and related pathways ofNrf2 and SIRT1/PGC-1α in     HepG2 cells[J]. Food and chemical toxicology, 2021, 158: 112696-112696.SCI二区top一作

DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells[J]. Ecotoxicology and environmental safety, 2021, 221: 112449-112449. SCI二区top一作

Effects of separate or combined exposure of nonylphenol and octylphenol on central 5-HT system and related learning and memory in the rats[J]. Ecotoxicology and Environmental Safety, 2019, 172: 523-529. SCI二区top一作

Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects[J]. Journal of Functional Foods,2017,32: 367-374.SCI一区top一作

Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway[J]. Molecules, 2021, 26(4): 859-859.SCI二区,IF=4.411一作

Effects of Phthalate Esters (PAEs) on Cell Viability and Nrf2 of HepG2 and 3D-QSAR Studies[J]. Toxics, 2021, 9(6) : 134-134.SCI二区,IF=4.146一作

Effects of ketogenic diet containing medium-chain fatty acids on serum inflammatory factor and mTOR signaling pathway in rats[J]. Chemical and Biological Technologies in Agriculture, 2020, 7(1): 1-9.SCI二区,一作

Intervention effect of gamma aminobutyric acid on anxiety behavior induced by phthalate (2-ethylhexyl ester) in rats[J]. International journal of neuroscience,2018:1-7.SCI四区,一作

桑葚粗提液对壬基酚诱导大鼠焦虑行为的干预作用及其机制[J].食品工业科技,2017,38(14):294-298. (北大核心,一作

广州地区蔬菜甲醛含量及人群甲醛暴露的初步风险评估[J]. 保鲜与加工, 2020, 20(02): 195-199. (北大核心,一作

一种桑葚多酚类物质粗提液的制备方法[P]. 广东省:CN110974870B,2021-08-31.(已公开,三作)

2021年全国商业科技进步奖二等奖,排名11